Sulfates are the foremost circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The principal oxidative metabolite is two-hydroxy ethinyl estradiol, fashioned through the CYP3A4 isoform of cytochrome P450. A part of the very first-go metabolism of ethinyl estradiol is believed to happen in gastrointestinal mucosa. Ethin